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Artículos publicados

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Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression.

Hernández-Ortego P, Torres-Montero R, De la Peña E, Viana F, Fernández-Trillo J.
Int J Mol Sci. 2022 Dec 18;23(24):16164. doi: 10.3390/ijms232416164.

PMID: 36555804 Free PMC article.

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TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine.

Alarcón-Alarcón D, Cabañero D, de Andrés-López J, Nikolaeva-Koleva M, Giorgi S, Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A.
Nat Commun. 2022 Oct 22;13(1):6304. doi: 10.1038/s41467-022-33835-3.
PMID: 36272975 Free PMC article.

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The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature.

Reimúndez A, Fernández-Peña C, Ordás P, Hernández-Ortego P, Gallego R, Morenilla-Palao C, Navarro J, Martín-Cora F, Pardo-Vázquez JL, Schwarz LA, Arce V, Viana F, Señarís R.
Acta Physiol (Oxf). 2022 Oct 17:e13896. doi: 10.1111/apha.13896.
Online ahead of print.

PMID: 36251565

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ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention.

Cabañero D, Villalba-Riquelme E, Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A.
Pharmacol Ther. 2022 Oct 4;240:108297. doi: 10.1016/j.pharmthera.2022.108297. Online ahead of print.
PMID: 36202261 Review.

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TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy.

Fernández-Carvajal A, Fernández-Ballester G, Ferrer-Montiel A.
Front Mol Neurosci. 2022 Sep 2;15:930964. doi: 10.3389/fnmol.2022.930964. eCollection 2022.
PMID: 36117910 Free PMC article. Review.

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TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.

Marcotti A, Fernández-Trillo J, González A, Vizcaíno-Escoto M, Ros-Arlanzón P, Romero L, Vela JM, Gomis A, Viana F, de la Peña E.
Brain. 2022 Jul 24:awac273. doi: 10.1093/brain/awac273. Online ahead
of print.

PMID: 35871491

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Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats.

Villalba-Riquelme E, de la Torre-Martínez R, Fernández-Carvajal A, Ferrer-Montiel A.
Br J Pharmacol. 2022 Jul;179(14):3693-3710. doi: 10.1111/bph.15809. Epub 2022 Mar 7.
PMID: 35102580

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β-Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models.

Martín-Escura C, Medina-Peris A, Spear LA, de la Torre Martínez R, Olivos-Oré LA, Barahona MV, González-Rodríguez S, Fernández-Ballester G, Fernández-Carvajal A, Artalejo AR, Ferrer-Montiel A, González-Muñiz R.
Int J Mol Sci. 2022 Feb 28;23(5):2692. doi: 10.3390/ijms23052692.
PMID: 35269831 Free PMC article.

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DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target.

Butrón D, Zamora-Carreras H, Devesa I, Treviño MA, Abian O, Velázquez-Campoy A, Bonache MÁ, Lagartera L, Martín-Martínez M, González-Rodríguez S, Baamonde A, Fernández-Carvajal A, Ferrer-Montiel A, Jiménez MÁ, González-Muñiz R.
Bioorg Chem. 2021 Oct;115:105231. doi: 10.1016/j.bioorg.2021.105231. Epub 2021 Jul 31.
PMID: 34388485

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Structural and in Vitro Functional Characterization of a Menthyl TRPM8 Antagonist Indicates Species-Dependent Regulation.

Journigan VB, Alarcón-Alarcón D, Feng Z, Wang Y, Liang T, Dawley DC, Amin ARMR, Montano C, Van Horn WD, Xie XQ, Ferrer-Montiel A, Fernández-Carvajal A.
ACS Med Chem Lett. 2021 Mar 31;12(5):758-767. doi: 10.1021/acsmedchemlett.1c00001. eCollection 2021 May 13.
PMID: 34055223 Free PMC article.

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Phenylalanine-Derived β-Lactam TRPM8 Modulators. Configuration Effect on the Antagonist Activity.

Bonache MÁ, Llabrés PJ, Martín-Escura C, De la Torre-Martínez R, Medina-Peris A, Butrón L, Gómez-Monterrey I, Roa AM, Fernández-Ballester G, Ferrer-Montiel A, Fernández-Carvajal A, González-Muñiz R.
Int J Mol Sci. 2021 Feb 27;22(5):2370. doi: 10.3390/ijms22052370.
PMID: 33673444 Free PMC article.

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A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability.

Nikolaeva-Koleva M, Butron L, González-Rodríguez S, Devesa I, Valente P, Serafini M, Genazzani AA, Pirali T, Ballester GF, Fernández-Carvajal A, Ferrer-Montiel A.
Sci Rep. 2021 Jan 8;11(1):246. doi: 10.1038/s41598-020-80725-z.
PMID: 33420359 Free PMC article.

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Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification.

Dionisi M, Ruffinatti FA, Riva B, Lim D, Canta A, Meregalli C, Fumagalli G, Monza L, Ferrer-Montiel A, Fernandez-Carvajal A, Cavaletti G, Genazzani AA, Distasi C.
Int J Mol Sci. 2020 Sep 28;21(19):7164. doi: 10.3390/ijms21197164.
PMID: 32998392 Free PMC article.

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Targeting thermoTRP ion channels: in silico preclinical approaches and opportunities.

Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A.
Expert Opin Ther Targets. 2020 Nov;24(11):1079-1097. doi: 10.1080/14728222.2020.1820987. Epub 2020 Sep 24.
PMID: 32972264 Review.

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Investigational drugs in early phase clinical trials targeting thermotransient receptor potential (thermoTRP) channels.

Fernández-Carvajal A, González-Muñiz R, Fernández-Ballester G, Ferrer-Montiel A.
Expert Opin Investig Drugs. 2020 Nov;29(11):1209-1222. doi: 10.1080/13543784.2020.1825680. Epub 2020 Sep 29.
PMID: 32941080 Review.

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